Cytotoxic diarylheptanoid induces cell cycle arrest and apoptosis via increasing ATF3 and stabilizing p53 in SH-SY5Y cells
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چکیده
منابع مشابه
Vincristine induces cell cycle arrest and apoptosis in SH-SY5Y human neuroblastoma cells.
Neuroblastoma is a common childhood tumor. Vincristine (VCR), an alkaloid extracted from Catharanthus roseus, is commonly used in combination chemotherapy. However, the mechanisms of VCR-induced neuroblastoma cell death are not clear. The aim of this study was to investigate the impact of VCR on mitosis and apoptosis of SH-SY5Y neuroblastoma cells...
متن کاملHonokiol induces cell cycle arrest and apoptosis via p53 activation in H4 human neuroglioma cells.
OBJECTIVE To investigate the signal pathway of honokiol-induced apoptosis in H4 human neuroglioma cells and to evaluate whether p53 signaling and cell cycle arrest were involved in honokiol-treated H4 human neuroglioma cells. METHODS The cell viability was detected by the CCK8 assay. The cell apoptosis was assessed by annexin V-PI double-labeling staining and hoechst 33342 staining. The prote...
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The aim of the present study was to determine cytotoxic activity of crude methanolicextract of Echinophora platyloba on breast cancer MDA-MB-231 cell line. The free radicalscavenging effects of methanolic extract of E. platyloba were tested using DPPH method.Crude methanolic extract exhibited potential antioxidant activity with an IC50 value of 234.28 ±21.63 μg/mL when compared to the standard ...
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The aim of the present study was to determine cytotoxic activity of crude methanolicextract of Echinophora platyloba on breast cancer MDA-MB-231 cell line. The free radicalscavenging effects of methanolic extract of E. platyloba were tested using DPPH method.Crude methanolic extract exhibited potential antioxidant activity with an IC50 value of 234.28 ±21.63 μg/mL when compared to the standard ...
متن کاملQuercetin induces cell cycle arrest and apoptosis in CD133+ cancer stem cells of human colorectal HT29 cancer cell line and enhances anticancer effects of doxorubicin
Objective(s):The colorectal cancer stem cells (CSCs) with the CD133+ phenotype are a rare fraction of cancer cells with the ability of self-renewal, unlimited proliferation and resistance to treatment. Quercetin has anticancer effects with the advantage of exhibiting low side effects. Therefore, we evaluated the anticancer effects of quercetin and doxorubicin (Dox) in HT29 cancer cells and its ...
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ژورنال
عنوان ژورنال: Cancer Chemotherapy and Pharmacology
سال: 2008
ISSN: 0344-5704,1432-0843
DOI: 10.1007/s00280-008-0832-5